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COVID-19 Vaccine Update

Posted on May 13, 2021

At Grand Rapids Allergy, we are encouraged by the availability of the COVID-19 vaccine for adolescents age 12 and older. We recognize that you may have questions. It is always appropriate to consult with a primary care provider/pediatrician about vaccine questions as they should have your most complete health history and current health status. People with a known history of a severe allergic reaction to any component of the COVID-19 vaccine should not get the vaccine. People with a history of reactions to other vaccines/vaccine components or injectable medications should use caution and are encouraged to consult with an allergist to discuss potential risk. Those who have allergies (such as allergies to pollen/mold/pets, food, venom, latex, and non-injectable drugs) are not considered more likely to have an allergic reaction to the vaccine than the general public. An appointment with a provider is an appropriate next step if there are additional questions or need documentation authorizing vaccination. We have linked online resources about the vaccine program and benefits of being vaccinated.

We advise 24-48 hours before or after COVID vaccination to have your routine immunotherapy dose. However, there may be exceptions to this guidance and we welcome a visit to review your individual situation. Side effects for the coronavirus vaccine may be more frequent than influenza vaccine and other vaccines. A longer period between vaccine and allergy immunotherapy is suggested until more data is available.

Below is an updated statement by the American College of Allergy, Asthma, and Immunology (ACAAI) that addresses other common concerns. Previous statements are available on our site. Here is a link with information about safety, efficacy and vaccine administration from the American Academy of Pediatrics (AAP).

ACAAI Updates to Guidance on Risk of Allergic Reactions to COVID-19 Vaccines

Guidance now includes information on the adenovirus vector Johnson & Johnson vaccine

UPDATED: April 26, 2021

The American College of Allergy, Asthma and Immunology (ACAAI) COVID-19 Vaccine Task Force continues to closely monitor information from sources reporting on allergic reactions to the COVID-19 vaccines. As such, ACAAI has updated its guidance to reflect the most recent recommendations from the CDC and the FDA.

Reactions to vaccines, in general, are rare with the occurrence of anaphylaxis estimated at 1.31 in 1 million doses given. Subsequent to the FDA emergency use authorization of the mRNA-based Pfizer-BioNTech COVID-19 vaccine on Dec. 11, 2020, and the Moderna vaccine on Dec. 18, 2020, anaphylaxis rates as of Jan. 29, 2021 are reported by the CDC to be five per million with Pfizer-BioNTech and 2.5 per million with Moderna. The anaphylaxis rate for the Johnson & Johnson COVID-19 vaccine has not been reported.

The ACAAI COVID-19 Vaccine Task Force recommends the following guidance related to risk of an allergic reaction on vaccination.

These recommendations are based on best knowledge to date but could change at any time, pending new information and further guidance from the FDA, CDC.

  1. Anyone receiving the vaccine should be screened to determine possible risk of an allergic reaction to the mRNA (Moderna and Pfizer) and adenovirus vector (Johnson & Johnson) COVID-19 vaccines. You should be asked if you have a history of a severe allergic reaction to any prior vaccine. If the answer is yes, you should be referred to a board-certified allergist/immunologist for further evaluation prior to COVID-19 vaccination.
  2. According to the CDC, if you have had a severe or an immediate allergic reaction of any severity within 4 hours after getting the first COVID-19 shot, you should not get the second shot. Additionally, patients who experience a severe or an immediate allergic reaction of any severity (hives, swelling, wheezing) or who have questions related to risk of an allergic reaction, may be referred to a local board-certified allergist/immunologist to provide more care or advice.
  3. The COVID-19 vaccines should be administered in a health care setting where anaphylaxis can be treated. All individuals must be observed for at least 15-30 minutes after injection to monitor for any adverse reaction. All anaphylactic reactions should be managed immediately with epinephrine as the first line treatment. Most anaphylactic reactions have occurred within 15 minutes.
  4. The mRNA and adenovirus vector COVID-19 vaccines should not be administered to individuals with a known history of a severe allergic reaction to any component of a particular vaccine. Although the specific vaccine component causing the anaphylaxis has not been identified, polyethylene glycol (PEG) is one of the ingredients in the mRNA vaccines and has been known to cause anaphylaxis. Polysorbate 80 is an ingredient in the Johnson & Johnson vaccine which may cause anaphylaxis and may cross-react with PEG.

Patients with allergic reactions to PEG should not be immunized with the mRNA COVID-19 vaccines. Consideration may be given to vaccination with adenovirus vector COVID-19 vaccine.

The CDC recommends that the adenovirus vector vaccine may be an option instead of a second dose of an mRNA vaccine for patients who had an adverse reaction to the mRNA product. People who have received one mRNA COVID-19 vaccine dose but for whom the second dose is contraindicated should wait at least 28 days after the mRNA vaccine dose to receive the adenovirus vector COVID-19 vaccine. These patients should have the vaccine in a setting able to treat anaphylaxis and observed a minimum of 30 minutes after the injection.

In patients with a contraindication to adenovirus vector COVID-19 vaccine (including due to a known polysorbate allergy), there should be consideration of administering the mRNA COVID-19 vaccination.

Per CDC guidance, polysorbate allergy is no longer a contraindication to mRNA COVID-19 vaccination, it is a precaution. However, because of potential cross-reactive hypersensitivity between ingredients in mRNA and adenovirus vector COVID-19 vaccines, consultation with an allergist-immunologist should be considered to help determine if the patient can safely receive vaccination.If the mRNA vaccine is given in a patient with polysorbate allergy, it should be done in a setting able to treat anaphylaxis and the patient observed a minimum of 30 minutes after the injection.

  1. Data regarding risk in individuals with a history of allergic reactions related to mast cell activation syndrome/idiopathic anaphylaxis is very limited and evolving. A decision to receive COVID-19 vaccines should be undertaken by you with your physician or other provider administering the vaccine using their professional judgment balancing the benefits and risks associated with taking the vaccine.
  2. People with common allergies to medications, foods, inhalants, insects, and latex are probably no more likely than the general public to have an allergic reaction to the mRNA COVID-19 vaccines. Those patients should be informed of the benefits of the vaccine versus its risks.
  3. The mRNA and adenovirus vector COVID-19 vaccines are not live vaccines and can be administered to immunocompromised patients. Physicians and other providers should inform immunocompromised patients of the possibility of a diminished immune response to the vaccines.
  4. Infrequently, people who have received dermal fillers may develop swelling at or near the site of filler injection (usually face or lips) following administration of a dose of an mRNA COVID-19 vaccine. This appears to be temporary and can resolve with medical treatment, including corticosteroid therapy. mRNA and adenovirus vector COVID-19 vaccines may be administered to people who have received injectable dermal fillers who have no contraindications to vaccination. No additional precautions are needed. However, these people should be advised to contact their health care provider for evaluation if they develop swelling at or near the site of dermal filler following vaccination.
  5. If you are receiving the mRNA COVID vaccine, you should expect local (e.g., pain, swelling, skin rash at the injection site, some swelling of the lymph nodes on the same side as the vaccinated arm) and systemic (e.g., fever, fatigue, headache, chills, muscle pain, joint pain, or inflammation) post-vaccination symptoms. These are expected side effects, not allergic reactions. They usually resolve within a few days.
  6. Note: Following a 10-day pause, the CDC and FDA have recommended that use of Johnson & Johnson’s Janssen (J&J/Janssen) COVID-19 vaccine resume in the United States, effective April 23, 2021. However, women younger than 50 years old should be aware of the rare risk of blood clots with low platelets after vaccination, and that other COVID-19 vaccines are available where this risk has not been seen. If you received a J&J/Janssen vaccine, here is what you need to know. Read the CDC/FDA statement.


Banerji A, Wickner PG, Saff R, Stone CA Jr, Robinson LB, Long AA, Wolfson AR, Williams P, Khan DA, Phillips E, Blumenthal KG, mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach, The Journal of Allergy and Clinical Immunology: In Practice (2021)

CDC: Lab Tests to Collect Shortly After Severe Allergic Reaction/Anaphylaxis Following COVID-19 Vaccination

CDC: Information about COVID-19 Vaccines for People with Allergies

CDC: What to Do if You Have an Allergic Reaction After Getting A COVID-19 Vaccine

CDC: Clinical Considerations for COVID-19 Vaccination

CDC: Interim Clinical Considerations for Use of mRNA COVID-19 Vaccines Currently Authorized in the United States

McNeil MM, Weintraub ES, Duffy J, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016; 137(3):868-878.

Dreskin et al. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organization Journal 2016; 9:32.

Wylon, K., Dölle, S. & Worm, M. Polyethylene glycol as a cause of anaphylaxis. J Allergy Asthma Clin Immunol. 12, 67 (2016).

Stone CA, Liu Y, et al. Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized. J Allergy Clin Immunol Pract. 2019; 7(5): 1533–1540.

Insights from American College of Allergy, Asthma and Immunology COVID-19 Vaccine Task Force: Allergic Reactions to mRNA SARS-COV-2 Vaccines. Annals of Allergy, Asthma & Immunology, January 2021.

Grand Rapids Allergy has served the west Michigan area for over 40 years. We’re working to treat allergies at the root level with personalized treatment plans based on your unique allergy profile.

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